Soluble c1 reactions - role of the acidic insert?

Electron transfer kinetics between soluble modules of Paracoccus denitrificans cytochrome c₁ and its physiological redox partners
Pages 250-259
Julia Janzon, Anna Carina Eichhorn, Bernd Ludwig, Francesco Malatesta

Center N/Qi mutations

Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc₁ complex
Pages 239-249
Frederik A.J. Rotsaert, Raul Covian, Bernard L. Trumpower

Requirement for mobility of ISP tested by cross-linking in the distal/c1 position

Formation of engineered intersubunit disulfide bond in cytochrome bc₁ complex disrupts electron transfer activity in the complex

He-Wen Ma, Shaoqing Yang, Linda Yu and Chang-An Yu

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1777, Issue 3, March 2008, Pages 317-326

Methods paper-

Methods Mol Biol. 2008;432:65-81.

Preparation of Respiratory Chain Complexes from Saccharomyces cerevisiae Wild-Type and Mutant Mitochondria : Activity Measurement and Subunit Composition Analysis.

Lemaire C, Dujardin G.

CNRS, Centre de Génétique Moléculaire, Gif sur Yvette, France.

Highest resolution bc1 structure; cyt c bound; asymmetric dimer

J Biol Chem. 2008 Apr 4 [Epub ahead of print]

Related Articles, Links

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

Solmaz S, Hunte C.

University of Leeds, Leeds LS2 9JT.

Possible arrangement of respiratory complexes in supercomplex

Schäfer E, Dencher NA, Vonck J, Parcej DN.

Three-dimensional structure of the respiratory chain supercomplex I(1)III(2)IV(1) from bovine heart mitochondria.

Biochemistry. 2007 Nov 6;46(44):12579-85

Redox-dependent inhibitor binding, implications for conformational switch

Domain movement of iron sulfur protein in cytochrome bc₁ complex is facilitated by the electron transfer from cytochrome b_L to b_H

Xiaowei Cen, Linda Yu and Chang-An Yu

FEBS Letters 582 (2008) 523-526

Qi-site inhibitor specificity

Frederik A.J. Rotsaert, Martina G. Ding and Bernard L. Trumpower

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc₁ complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1777, Issue 2, February 2008, Pages 211-219

http://dx.doi.org/10.1016/j.bbabio.2007.10.011

Dispensibility of E272 for quinol oxidation

Biochemistry, ASAP Article 10.1021/bi701905a S0006-2960(70)01905-0
Web Release Date: January 24, 2008

Is Cytochrome b Glutamic Acid 272 a Quinol Binding Residue in the bc₁ Complex of Saccharomyces cerevisiae?

Nadir Seddiki, Brigitte Meunier, Danielle Lemesle-Meunier, and Gaël Brasseur

regulation of supercomplexes

Sonika Saddar, Mary K. Dienhart, and Rosemary A. Stuart
The F1Fo-ATP synthase complex influences the assembly state of the cytochrome bc1-cytochrome oxidase supercomplex and its association with the TIM23 machinery
J. Biol. Chem, 10.1074/jbc.M708440200
The latest version is at
http://www.jbc.org/cgi/doi/10.1074/jbc.M708440200

Posible link between Complex III and hypertension?

Huynh H, Servant N, Chalifour LE.
Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension.
Can J Physiol Pharmacol. 2007 Oct;85(10):986-996.
PMID: 18066099

New structures!

Esser L, Elberry M, Zhou F, Yu CA, Yu L, Xia D.
Inhibitor complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides.
J Biol Chem. 2007 Nov 26; PMID: 18039651

New Article

Baer KK, McClellan DA.
Molecular coevolution of the vertebrate cytochrome c1 and Rieske Iron Sulphur Protein in the cytochrome bc1 complex. Int J Bioinform Res Appl. 2007;3(4):456-70. PMID: 18048312

New article

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.

Kessl JJ, Meshnick SR, Trumpower BL.
Trends Parasitol. 2007 Oct;23(10):494-501.

Why some pathogens don't develop resistance to Qo Inhibitors:

Derek Hollomon: Are some diseases unlikely to develop QoI resistance? Pest Management Science 63; 217-218
Helge Sierotzki *, Regula Frey, Jürg Wullschleger, Simona Palermo, Serge Karlin, Jeremy Godwin, Ulrich Gisi: Cytochrome b gene sequence and structure of Pyrenophora teres and P. tritici-repentis and implications for QoI resistance. Pest Management Science 63; 225-233

New Article- SQ at Qi - more evidence for His involvement

Sergei A. Dikanov, J. Todd Holland, Burkhard Endeward, Derrick R. J. Kolling, Rimma I. Samoilova, Thomas F. Prisner, and Antony R. Crofts
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex
J. Biol. Chem, 10.1074/jbc.M702333200

New Article - More on the asymmetric dimer

Covian RG, Zwicker K, Rotsaert FA, Trumpower BL.
Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex: Consequences for semiquinone stabilization.
J Biol Chem. 2007 Jun 21; [Epub ahead of print]
PMID: 17584742

New article: another sighting of the SQo semiquinone?

	Zhang H, Osyczka A, Dutton PL, Moser CC.
	Exposing the Complex III Qo semiquinone radical. Biochim Biophys Acta. 2007 May 1; [Epub ahead of print] PMID: 17560537

New Article: ROS production by Qo site in Complex III lacking cyt b???

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. Eric L. Bell, Tatyana A. Klimova, James Eisenbart, Carlos T. Moraes, Michael P. Murphy, G.R. Scott Budinger, and Navdeep S. Chandel
http://www.jcb.org/cgi/content/full/177/6/1029

New article

Shinkarev VP, Wraight CA. Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
FEBS Lett. 2007 Apr 17;581(8):1535-41. Epub 2007 Mar 26.