Derek Hollomon: Are some diseases unlikely to develop QoI resistance? Pest Management Science 63; 217-218
Helge Sierotzki *, Regula Frey, Jürg Wullschleger, Simona Palermo, Serge Karlin, Jeremy Godwin, Ulrich Gisi: Cytochrome b gene sequence and structure of Pyrenophora teres and P. tritici-repentis and implications for QoI resistance. Pest Management Science 63; 225-233
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Fischer and coworkers (Eur J Biochem 271; 2264-71) Looked at this question and decided other differences in the Qo site affected the severity of the penalty of the mutation for normal function. It turns out that at least for some of the species that don't develop resistance, there is a much more serious penalty: the single nucleotide change that brings about the mutation with greatest resistance (G143A) prevents excision of an intron immediately following this codon. Thus mRNA is not matured and cyt b is not made. That should help the folks at Syngenta sleep at night! If the wheat and grape crops are lost due to inhibitor resistant fungi we may have no bread or wine, but the potatoes should be alright.
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