Sunday, June 8, 2008

Recent Article

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex.
Stefan Drose and Ulrich Brandt
J. Biol. Chem., June 3, 2008

In-depth review from Urbana

The Q-cycle reviewed: How well does a monomeric mechanism of the bc1 complex account for the function of a dimeric complex?

Antony R. Crofts, J. Todd Holland, Doreen Victoria, Derrick R.J. Kolling, Sergei A. Dikanov, Ryan Gilbreth, Sangmoon Lhee, Richard Kuras and Mariana Guergova Kuras

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Article in Press, Corrected Proof
DOI 10.1016/j.bbabio.2008.04.037

Monday, May 26, 2008

New Atovaquone-resistance mutations:

Josephine E. Siregar, Din Syafruddin, Hiroyuki Matsuoka, Kiyoshi Kita and Sangkot Marzuki
Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone-binding-domain 2 (Qo2) of the cytochrome b gene

Parasitology International Volume 57,229-232

Saturday, May 10, 2008

Recent article:

Soluble Variants of Rhodobacter capsulatus Membrane-anchored Cytochrome cy Are Efficient Photosynthetic Electron Carriers

Yavuz Ozturk, Dong-Woo Lee, Sevnur Mandaci, Artur Osyczka, Roger C. Prince, and Fevzi Daldal

J. Biol. Chem. 2008; 283(20): p. 13964-13972

Recent article:

Cytochrome bc1-cy Fusion Complexes Reveal the Distance Constraints for Functional Electron Transfer Between Photosynthesis Components

Dong-Woo Lee, Yavuz Ozturk, Artur Osyczka, Jason W. Cooley, and Fevzi Daldal
J. Biol. Chem. 2008; 283(20): p. 13973-13982

Saturday, April 19, 2008

Methods paper-

Methods Mol Biol. 2008;432:65-81.
Click here to read
Preparation of Respiratory Chain Complexes from Saccharomyces cerevisiae Wild-Type and Mutant Mitochondria : Activity Measurement and Subunit Composition Analysis.

Lemaire C, Dujardin G.

CNRS, Centre de Génétique Moléculaire, Gif sur Yvette, France.

Highest resolution bc1 structure; cyt c bound; asymmetric dimer

Related Articles, Links
Click here to read
Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

Solmaz S, Hunte C.

University of Leeds, Leeds LS2 9JT.

Monday, February 18, 2008

Possible arrangement of respiratory complexes in supercomplex

Schäfer E, Dencher NA, Vonck J, Parcej DN.
Three-dimensional structure of the respiratory chain supercomplex I(1)III(2)IV(1) from bovine heart mitochondria.
Biochemistry. 2007 Nov 6;46(44):12579-85

Sunday, February 10, 2008

Redox-dependent inhibitor binding, implications for conformational switch

Domain movement of iron sulfur protein in cytochrome bc1 complex is facilitated by the electron transfer from cytochrome bL to bH

Xiaowei Cen, Linda Yu and Chang-An Yu

FEBS Letters 582 (2008) 523-526

Saturday, January 26, 2008

Qi-site inhibitor specificity

Frederik A.J. Rotsaert, Martina G. Ding and Bernard L. Trumpower

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1777, Issue 2, February 2008, Pages 211-219

http://dx.doi.org/10.1016/j.bbabio.2007.10.011

Thursday, January 24, 2008

Dispensibility of E272 for quinol oxidation

Biochemistry, ASAP Article 10.1021/bi701905a S0006-2960(70)01905-0
Web Release Date: January 24, 2008

Is Cytochrome b Glutamic Acid 272 a Quinol Binding Residue in the bc1 Complex of Saccharomyces cerevisiae?

Nadir Seddiki, Brigitte Meunier, Danielle Lemesle-Meunier, and Gaël Brasseur

Friday, January 11, 2008

regulation of supercomplexes

Sonika Saddar, Mary K. Dienhart, and Rosemary A. Stuart
The F1Fo-ATP synthase complex influences the assembly state of the cytochrome bc1-cytochrome oxidase supercomplex and its association with the TIM23 machinery
J. Biol. Chem, 10.1074/jbc.M708440200
The latest version is at
http://www.jbc.org/cgi/doi/10.1074/jbc.M708440200

Sunday, January 6, 2008

Posible link between Complex III and hypertension?

Huynh H, Servant N, Chalifour LE.
Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension.
Can J Physiol Pharmacol. 2007 Oct;85(10):986-996.
PMID: 18066099