New article

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.

Kessl JJ, Meshnick SR, Trumpower BL.
Trends Parasitol. 2007 Oct;23(10):494-501.

Why some pathogens don't develop resistance to Qo Inhibitors:

Derek Hollomon: Are some diseases unlikely to develop QoI resistance? Pest Management Science 63; 217-218
Helge Sierotzki *, Regula Frey, Jürg Wullschleger, Simona Palermo, Serge Karlin, Jeremy Godwin, Ulrich Gisi: Cytochrome b gene sequence and structure of Pyrenophora teres and P. tritici-repentis and implications for QoI resistance. Pest Management Science 63; 225-233

New Article- SQ at Qi - more evidence for His involvement

Sergei A. Dikanov, J. Todd Holland, Burkhard Endeward, Derrick R. J. Kolling, Rimma I. Samoilova, Thomas F. Prisner, and Antony R. Crofts
Hydrogen bonds between nitrogen donors and the semiquinone in the Qi-site of the bc1 complex
J. Biol. Chem, 10.1074/jbc.M702333200

New Article - More on the asymmetric dimer

Covian RG, Zwicker K, Rotsaert FA, Trumpower BL.
Asymmetric and redox-specific binding of quinone and quinol at center N of the dimeric yeast cytochrome bc1 complex: Consequences for semiquinone stabilization.
J Biol Chem. 2007 Jun 21; [Epub ahead of print]
PMID: 17584742

New article: another sighting of the SQo semiquinone?

	Zhang H, Osyczka A, Dutton PL, Moser CC.
	Exposing the Complex III Qo semiquinone radical. Biochim Biophys Acta. 2007 May 1; [Epub ahead of print] PMID: 17560537

New Article: ROS production by Qo site in Complex III lacking cyt b???

The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. Eric L. Bell, Tatyana A. Klimova, James Eisenbart, Carlos T. Moraes, Michael P. Murphy, G.R. Scott Budinger, and Navdeep S. Chandel
http://www.jcb.org/cgi/content/full/177/6/1029

New article

Shinkarev VP, Wraight CA. Intermonomer electron transfer in the bc1 complex dimer is controlled by the energized state and by impaired electron transfer between low and high potential hemes.
FEBS Lett. 2007 Apr 17;581(8):1535-41. Epub 2007 Mar 26.

New article

Structure of the Cytochrome b(6)f Complex: Quinone Analogue Inhibitors as Ligands of Heme c(n).

Yamashita E, Zhang H, Cramer WA.
J Mol Biol. 2007 Jun 29;370(1):39-52. Epub 2007 Apr 12.

New article - anticooperative dimer

Raul G. Covian, Thomas Kleinschroth, Bernd A. Ludwig, and Bernard L. Trumpower.
Asymmetric binding of stigmatellin to the dimeric Paracoccus denitrificans bc1 complex: Evidence for anti-cooperative ubiquinol oxidation and communication between center P ubiquinol oxidation sites. J. Biol. Chem. published 8 June 2007, 10.1074/jbc.M702132200

Recent article: Rieske proton ENDOR

Probing electronic and structural properties of the reduced [2Fe-2S] cluster by orientation-selective H-1 ENDOR spectroscopy: Adrenodoxin versus Rieske iron-sulfur protein
Kappl R, Ebelshauser M, Hannemann F, Bernhardt R, Huttermann J(2006) APPLIED MAGNETIC RESONANCE 30 (3-4): 427-459

New Article

Jonathan L. Cape, Michael K. Bowman, and David M. Kramer.
A semiquinone intermediate generated at the Qo site of the cytochrome bc1 complex: Importance for the Q-cycle and superoxide production.
PNAS. published 30 April 2007, 10.1073/pnas.0702621104

New Article:

Kessl JJ, Moskalev NV, Gribble GW, Nasr M, Meshnick SR, Trumpower BL.
Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc(1) complex.
Biochim Biophys Acta. 2007 Feb 27; [Epub ahead of print]
PMID: 17383607

Recent Article

Molecular Coevolution of the Vertebrate Cytochrome c1 and Rieske Iron Sulfur Protein in the Cytochrome bc1 Complex
Kimberly Baer, David A. McClellan http://www.biotconf.org/2006/3-Mcclellan-28.pdf

New Article

Jian Zhu, Tsuyoshi Egawa , Syun-Ru Yeh , Linda Yu, and Chang-An Yu. Simultaneous reduction of iron-sulfur protein and cytochrome bL during ubiquinol oxidation in cytochrome bc1 complex. Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0607812104

Recent Article

Lebrun E, Santini JM, Brugna M, Ducluzeau AL, Ouchane S, Schoepp-Cothenet B, Baymann F, Nitschke W. The Rieske protein: a case study on the pitfalls of multiple sequence alignments and phylogenetic reconstruction.
Mol Biol Evol. 2006 Jun;23(6):1180-91. Epub 2006 Mar 28.
PMID: 16569761

Recent Article

Zatsman AI, Zhang H, Gunderson WA, Cramer WA, Hendrich MP. Heme-heme interactions in the cytochrome b6f complex: EPR spectroscopy and correlation with structure.
J Am Chem Soc. 2006 Nov 8;128(44):14246-7. PMID: 17076484

For new questions, comments:

Only moderators can initiate new posts. Anyone can add a comment to an existing post, but the comment should be related. So this entry is for general questions or comments not related to any of the articles. Feel free to chime in!

Astrid R. Klingen, Hildur Palsdottir, Carola Hunte and G. Matthias Ullmann
Redox-linked protonation state changes in cytochrome bc1 identified by Poisson–Boltzmann electrostatics calculations
Biochimica et Biophysica Acta (BBA) - Bioenergetics
Article in Press, Uncorrected Proof - doi:10.1016/j.bbabio.2007.01.016

Wenz T, Covian R, Hellwig P, Macmillan F, Meunier B, Trumpower BL, Hunte C.
Mutational Analysis of Cytochrome b at the Ubiquinol Oxidation Site of Yeast Complex III.
J Biol Chem. 2007 Feb 9;282(6):3977-88. Epub 2006 Dec 4.
PMID: 17145759

A Comparison of Stigmatellin Conformations, Free and Bound to the Photosynthetic Reaction Center and the Cytochrome bc1 Complex
Journal of Molecular Biology, In Press, Accepted Manuscript, Available online 11 February 2007,
C. Roy D. Lancaster, Carola Hunte, Jack Kelley III, Bernard L. Trumpower and Robert Ditchfield
PDF (1029 K)