Recent Article

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex.
Stefan Drose and Ulrich Brandt
J. Biol. Chem., June 3, 2008

In-depth review from Urbana

The Q-cycle reviewed: How well does a monomeric mechanism of the bc1 complex account for the function of a dimeric complex?

Antony R. Crofts, J. Todd Holland, Doreen Victoria, Derrick R.J. Kolling, Sergei A. Dikanov, Ryan Gilbreth, Sangmoon Lhee, Richard Kuras and Mariana Guergova Kuras

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Article in Press, Corrected Proof
DOI 10.1016/j.bbabio.2008.04.037

New Atovaquone-resistance mutations:

Josephine E. Siregar, Din Syafruddin, Hiroyuki Matsuoka, Kiyoshi Kita and Sangkot Marzuki
Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone-binding-domain 2 (Qo2) of the cytochrome b gene

Parasitology International Volume 57,229-232

Recent article:

Soluble Variants of Rhodobacter capsulatus Membrane-anchored Cytochrome cy Are Efficient Photosynthetic Electron Carriers

Yavuz Ozturk, Dong-Woo Lee, Sevnur Mandaci, Artur Osyczka, Roger C. Prince, and Fevzi Daldal

J. Biol. Chem. 2008;  283(20): p. 13964-13972

Recent article:

Cytochrome bc1-cy Fusion Complexes Reveal the Distance Constraints for Functional Electron Transfer Between Photosynthesis Components

Dong-Woo Lee, Yavuz Ozturk, Artur Osyczka, Jason W. Cooley, and Fevzi Daldal
  J. Biol. Chem. 2008;  283(20): p. 13973-13982

Soluble c1 reactions - role of the acidic insert?

Electron transfer kinetics between soluble modules of Paracoccus denitrificans cytochrome c₁ and its physiological redox partners
Pages 250-259
Julia Janzon, Anna Carina Eichhorn, Bernd Ludwig, Francesco Malatesta

Center N/Qi mutations

Mutations in cytochrome b that affect kinetics of the electron transfer reactions at center N in the yeast cytochrome bc₁ complex
Pages 239-249
Frederik A.J. Rotsaert, Raul Covian, Bernard L. Trumpower

Requirement for mobility of ISP tested by cross-linking in the distal/c1 position

Formation of engineered intersubunit disulfide bond in cytochrome bc₁ complex disrupts electron transfer activity in the complex

He-Wen Ma, Shaoqing Yang, Linda Yu and Chang-An Yu

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1777, Issue 3, March 2008, Pages 317-326

Methods paper-

Methods Mol Biol. 2008;432:65-81.

Preparation of Respiratory Chain Complexes from Saccharomyces cerevisiae Wild-Type and Mutant Mitochondria : Activity Measurement and Subunit Composition Analysis.

Lemaire C, Dujardin G.

CNRS, Centre de Génétique Moléculaire, Gif sur Yvette, France.

Highest resolution bc1 structure; cyt c bound; asymmetric dimer

J Biol Chem. 2008 Apr 4 [Epub ahead of print]

Related Articles, Links

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

Solmaz S, Hunte C.

University of Leeds, Leeds LS2 9JT.

Possible arrangement of respiratory complexes in supercomplex

Schäfer E, Dencher NA, Vonck J, Parcej DN.

Three-dimensional structure of the respiratory chain supercomplex I(1)III(2)IV(1) from bovine heart mitochondria.

Biochemistry. 2007 Nov 6;46(44):12579-85

Redox-dependent inhibitor binding, implications for conformational switch

Domain movement of iron sulfur protein in cytochrome bc₁ complex is facilitated by the electron transfer from cytochrome b_L to b_H

Xiaowei Cen, Linda Yu and Chang-An Yu

FEBS Letters 582 (2008) 523-526

Qi-site inhibitor specificity

Frederik A.J. Rotsaert, Martina G. Ding and Bernard L. Trumpower

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc₁ complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

Biochimica et Biophysica Acta (BBA) - Bioenergetics
Volume 1777, Issue 2, February 2008, Pages 211-219

http://dx.doi.org/10.1016/j.bbabio.2007.10.011

Dispensibility of E272 for quinol oxidation

Biochemistry, ASAP Article 10.1021/bi701905a S0006-2960(70)01905-0
Web Release Date: January 24, 2008

Is Cytochrome b Glutamic Acid 272 a Quinol Binding Residue in the bc₁ Complex of Saccharomyces cerevisiae?

Nadir Seddiki, Brigitte Meunier, Danielle Lemesle-Meunier, and Gaël Brasseur

regulation of supercomplexes

Sonika Saddar, Mary K. Dienhart, and Rosemary A. Stuart
The F1Fo-ATP synthase complex influences the assembly state of the cytochrome bc1-cytochrome oxidase supercomplex and its association with the TIM23 machinery
J. Biol. Chem, 10.1074/jbc.M708440200
The latest version is at
http://www.jbc.org/cgi/doi/10.1074/jbc.M708440200

Posible link between Complex III and hypertension?

Huynh H, Servant N, Chalifour LE.
Ubiquinol-cytochrome-c reductase 7.2 kDa protein of mitochondrial complex III is steroid-responsive and increases in cardiac hypertrophy and hypertension.
Can J Physiol Pharmacol. 2007 Oct;85(10):986-996.
PMID: 18066099